Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia : Suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample
Identifieur interne : 009F12 ( Main/Exploration ); précédent : 009F11; suivant : 009F13Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia : Suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample
Auteurs : Brian K. Suarez [États-Unis] ; Jubao Duan [États-Unis] ; Alan R. Sanders [États-Unis] ; Anthony L. Hinrichs [États-Unis] ; Carol H. Jin [États-Unis] ; CUIPING HOU [États-Unis] ; Nancy G. Buccola [États-Unis] ; Nancy Hale [États-Unis] ; Ann N. Weilbaecher [États-Unis] ; Deborah A. Nertney [Australie] ; Ann Olincy [États-Unis] ; Susan Green [États-Unis] ; Arthur W. Schaffer [États-Unis] ; Christopher J. Smith [États-Unis] ; Dominique E. Hannah [Australie] ; John P. Rice [États-Unis] ; Nancy J. Cox [États-Unis] ; Maria Martinez [États-Unis, France] ; Bryan J. Mowry [Australie] ; Farooq Amin [États-Unis] ; Jeremy M. Silverman [États-Unis] ; Donald W. Black [États-Unis] ; William F. Byerley [États-Unis] ; Raymond R. Crowe [États-Unis] ; Robert Freedman [États-Unis] ; C. Robert Cloninger [États-Unis] ; Douglas F. Levinson [États-Unis] ; Pablo V. Gejman [États-Unis]Source :
- American journal of human genetics [ 0002-9297 ] ; 2006.
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- Pascal (Inist)
- Wicri :
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Abstract
We report the clinical characteristics of a schizophrenia sample of 409 pedigrees-263 of European ancestry (EA) and 146 of African American ancestry (AA)-together with the results of a genome scan (with a simple tandem repeat polymorphism interval of 9 cM) and follow-up fine mapping. A family was required to have a proband with schizophrenia (SZ) and one or more siblings of the proband with SZ or schizoaffective disorder. Linkage analyses included 403 independent full-sibling affected sibling pairs (ASPs) (279 EA and 124 AA) and 100 all-possible half-sibling ASPs (15 EA and 85 AA). Nonparametric multipoint linkage analysis of all families detected two regions with suggestive evidence of linkage at 8p23.3-q12 and llpll.2-q22.3 (empirical Z likelihood-ratio score [Zlr] threshold ≥2.65) and, in exploratory analyses, two other regions at 4p16.1-p15.32 in AA families and at 5p14.3-q11.2 in EA families. The most significant linkage peak was in chromosome 8p; its signal was mainly driven by the EA families. Zlr scores >2.0 in 8p were observed from 30.7 cM to 61.7 cM (Center for Inherited Disease Research map locations). The maximum evidence in the full sample was a multipoint Zlr of 3.25 (equivalent Kong-Cox LOD of 2.30) near D8S1771 (at 52 cM); there appeared to be two peaks, both telomeric to neuregulin 1 (NRG1). There is a paracentric inversion common in EA individuals within this region, the effect of which on the linkage evidence remains unknown in this and in other previously analyzed samples. Fine mapping of 8p did not significantly alter the significance or length of the peak. We also performed fine mapping of 4p16.3-p15.2, 5p15.2-q13.3, 10p15.3-p14, 10q25.3-q26.3, and 11p13-q23.3. The highest increase in Zlr scores was observed for 5p14.1-q12.1, where the maximum Zlr increased from 2.77 initially to 3.80 after fine mapping in the EA families.
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Affiliations:
- Australie, France, États-Unis
- Californie, Illinois, Pennsylvanie, Texas, État de New York, Île-de-France
- Chicago, Houston, Philadelphie, San Francisco, Évry (Essonne)
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Jin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Psychiatry and Genetics, Washington University</s1><s2>St. Louis</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>St. Louis</wicri:noRegion></affiliation></author><author><name sortKey="Cuiping Hou" sort="Cuiping Hou" uniqKey="Cuiping Hou" last="Cuiping Hou">CUIPING HOU</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>18 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Evanston, IL</wicri:noRegion></affiliation></author><author><name sortKey="Buccola, Nancy G" sort="Buccola, Nancy G" uniqKey="Buccola N" first="Nancy G." last="Buccola">Nancy G. Buccola</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Nursing, Louisiana State University Health Sciences Center</s1><s2>New Orleans</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Orleans</wicri:noRegion></affiliation></author><author><name sortKey="Hale, Nancy" sort="Hale, Nancy" uniqKey="Hale N" first="Nancy" last="Hale">Nancy Hale</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine</s1><s2>Iowa City</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>22 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Iowa City</wicri:noRegion></affiliation></author><author><name sortKey="Weilbaecher, Ann N" sort="Weilbaecher, Ann N" uniqKey="Weilbaecher A" first="Ann N." last="Weilbaecher">Ann N. 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Hannah</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Queensland Centre for Schizophrenia Mental Health Research, The Park, Centre for Mental Health</s1><s2>Wacol</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Wacol</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Psychiatry, University of Queensland</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Rice, John P" sort="Rice, John P" uniqKey="Rice J" first="John P." last="Rice">John P. Rice</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Psychiatry and Genetics, Washington University</s1><s2>St. Louis</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>St. Louis</wicri:noRegion></affiliation></author><author><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J." last="Cox">Nancy J. Cox</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Medicine, University of Chicago</s1><s2>Chicago</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>18 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Evanston, IL</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Méthodologie Statistique et Epidémiologie Génétique des Maladies Multifactorielles, Institut National de la Recherche et de la Santé Médicale</s1><s2>Evry</s2><s3>FRA</s3><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation></author><author><name sortKey="Mowry, Bryan J" sort="Mowry, Bryan J" uniqKey="Mowry B" first="Bryan J." last="Mowry">Bryan J. Mowry</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Queensland Centre for Schizophrenia Mental Health Research, The Park, Centre for Mental Health</s1><s2>Wacol</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Wacol</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Psychiatry, University of Queensland</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Amin, Farooq" sort="Amin, Farooq" uniqKey="Amin F" first="Farooq" last="Amin">Farooq Amin</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Atlanta VA Medical Center and Department of Psychiatry and Behavioral Sciences, Emory University</s1><s2>Atlanta</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Baylor College of Medicine</s1><s2>Houston</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Silverman, Jeremy M" sort="Silverman, Jeremy M" uniqKey="Silverman J" first="Jeremy M." last="Silverman">Jeremy M. Silverman</name><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>Department of Psychiatry, Mount Sinai School of Medicine</s1><s2>New York</s2><s3>USA</s3><sZ>14 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Black, Donald W" sort="Black, Donald W" uniqKey="Black D" first="Donald W." last="Black">Donald W. Black</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine</s1><s2>Iowa City</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>22 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Iowa City</wicri:noRegion></affiliation></author><author><name sortKey="Byerley, William F" sort="Byerley, William F" uniqKey="Byerley W" first="William F." last="Byerley">William F. Byerley</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Psychiatry, University of California at Irvine</s1><s2>Irvine</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Irvine</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Department of Psychiatry, University of California-San Francisco</s1><s2>San Francisco</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Crowe, Raymond R" sort="Crowe, Raymond R" uniqKey="Crowe R" first="Raymond R." last="Crowe">Raymond R. Crowe</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine</s1><s2>Iowa City</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>22 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Iowa City</wicri:noRegion></affiliation></author><author><name sortKey="Freedman, Robert" sort="Freedman, Robert" uniqKey="Freedman R" first="Robert" last="Freedman">Robert Freedman</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Psychiatry and Colorado Psychiatric Health, University of Colorado School of Medicine</s1><s2>Denver</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Denver</wicri:noRegion></affiliation></author><author><name sortKey="Cloninger, C Robert" sort="Cloninger, C Robert" uniqKey="Cloninger C" first="C. Robert" last="Cloninger">C. Robert Cloninger</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Psychiatry and Genetics, Washington University</s1><s2>St. Louis</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>St. Louis</wicri:noRegion></affiliation></author><author><name sortKey="Levinson, Douglas F" sort="Levinson, Douglas F" uniqKey="Levinson D" first="Douglas F." last="Levinson">Douglas F. Levinson</name><affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Department of Psychiatry, University of Pennsylvania</s1><s2>Philadelphia</s2><s3>USA</s3><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Philadelphie</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Gejman, Pablo V" sort="Gejman, Pablo V" uniqKey="Gejman P" first="Pablo V." last="Gejman">Pablo V. Gejman</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>18 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Evanston, IL</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0468036</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0468036 INIST</idno><idno type="RBID">Pascal:06-0468036</idno><idno type="wicri:Area/PascalFrancis/Corpus">004126</idno><idno type="wicri:Area/PascalFrancis/Curation">001F69</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">004002</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">004002</idno><idno type="wicri:doubleKey">0002-9297:2006:Suarez B:genomewide:linkage:scan</idno><idno type="wicri:Area/Main/Merge">00AA24</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1380238</idno><idno type="RBID">PMC:1380238</idno><idno type="wicri:Area/Pmc/Corpus">000037</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000037</idno><idno type="wicri:Area/Pmc/Curation">000037</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000037</idno><idno type="wicri:Area/Pmc/Checkpoint">002C07</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002C07</idno><idno type="wicri:Area/Ncbi/Merge">000169</idno><idno type="wicri:Area/Ncbi/Curation">000169</idno><idno type="wicri:Area/Ncbi/Checkpoint">000169</idno><idno type="wicri:doubleKey">0002-9297:2006:Suarez B:genomewide:linkage:scan</idno><idno type="wicri:Area/Main/Merge">00A290</idno><idno type="wicri:Area/Main/Curation">009F12</idno><idno type="wicri:Area/Main/Exploration">009F12</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia : Suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample</title><author><name sortKey="Suarez, Brian K" sort="Suarez, Brian K" uniqKey="Suarez B" first="Brian K." last="Suarez">Brian K. Suarez</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Psychiatry and Genetics, Washington University</s1><s2>St. Louis</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>St. Louis</wicri:noRegion></affiliation></author><author><name sortKey="Duan, Jubao" sort="Duan, Jubao" uniqKey="Duan J" first="Jubao" last="Duan">Jubao Duan</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>18 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Evanston, IL</wicri:noRegion></affiliation></author><author><name sortKey="Sanders, Alan R" sort="Sanders, Alan R" uniqKey="Sanders A" first="Alan R." last="Sanders">Alan R. Sanders</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>18 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Evanston, IL</wicri:noRegion></affiliation></author><author><name sortKey="Hinrichs, Anthony L" sort="Hinrichs, Anthony L" uniqKey="Hinrichs A" first="Anthony L." last="Hinrichs">Anthony L. Hinrichs</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Psychiatry and Genetics, Washington University</s1><s2>St. Louis</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>St. Louis</wicri:noRegion></affiliation></author><author><name sortKey="Jin, Carol H" sort="Jin, Carol H" uniqKey="Jin C" first="Carol H." last="Jin">Carol H. Jin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Psychiatry and Genetics, Washington University</s1><s2>St. Louis</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>St. Louis</wicri:noRegion></affiliation></author><author><name sortKey="Cuiping Hou" sort="Cuiping Hou" uniqKey="Cuiping Hou" last="Cuiping Hou">CUIPING HOU</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>18 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Evanston, IL</wicri:noRegion></affiliation></author><author><name sortKey="Buccola, Nancy G" sort="Buccola, Nancy G" uniqKey="Buccola N" first="Nancy G." last="Buccola">Nancy G. Buccola</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Nursing, Louisiana State University Health Sciences Center</s1><s2>New Orleans</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Orleans</wicri:noRegion></affiliation></author><author><name sortKey="Hale, Nancy" sort="Hale, Nancy" uniqKey="Hale N" first="Nancy" last="Hale">Nancy Hale</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine</s1><s2>Iowa City</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>22 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Iowa City</wicri:noRegion></affiliation></author><author><name sortKey="Weilbaecher, Ann N" sort="Weilbaecher, Ann N" uniqKey="Weilbaecher A" first="Ann N." last="Weilbaecher">Ann N. Weilbaecher</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University</s1><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University</wicri:noRegion></affiliation></author><author><name sortKey="Nertney, Deborah A" sort="Nertney, Deborah A" uniqKey="Nertney D" first="Deborah A." last="Nertney">Deborah A. Nertney</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Queensland Centre for Schizophrenia Mental Health Research, The Park, Centre for Mental Health</s1><s2>Wacol</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Wacol</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Psychiatry, University of Queensland</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Olincy, Ann" sort="Olincy, Ann" uniqKey="Olincy A" first="Ann" last="Olincy">Ann Olincy</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Psychiatry and Colorado Psychiatric Health, University of Colorado School of Medicine</s1><s2>Denver</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Denver</wicri:noRegion></affiliation></author><author><name sortKey="Green, Susan" sort="Green, Susan" uniqKey="Green S" first="Susan" last="Green">Susan Green</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Atlanta VA Medical Center and Department of Psychiatry and Behavioral Sciences, Emory University</s1><s2>Atlanta</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Schaffer, Arthur W" sort="Schaffer, Arthur W" uniqKey="Schaffer A" first="Arthur W." last="Schaffer">Arthur W. Schaffer</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Psychiatry and Genetics, Washington University</s1><s2>St. Louis</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>St. Louis</wicri:noRegion></affiliation></author><author><name sortKey="Smith, Christopher J" sort="Smith, Christopher J" uniqKey="Smith C" first="Christopher J." last="Smith">Christopher J. Smith</name><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>Department of Psychiatry, Mount Sinai School of Medicine</s1><s2>New York</s2><s3>USA</s3><sZ>14 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hannah, Dominique E" sort="Hannah, Dominique E" uniqKey="Hannah D" first="Dominique E." last="Hannah">Dominique E. Hannah</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Queensland Centre for Schizophrenia Mental Health Research, The Park, Centre for Mental Health</s1><s2>Wacol</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Wacol</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Psychiatry, University of Queensland</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Rice, John P" sort="Rice, John P" uniqKey="Rice J" first="John P." last="Rice">John P. Rice</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Psychiatry and Genetics, Washington University</s1><s2>St. Louis</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>St. Louis</wicri:noRegion></affiliation></author><author><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J." last="Cox">Nancy J. Cox</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Medicine, University of Chicago</s1><s2>Chicago</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>18 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Evanston, IL</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Méthodologie Statistique et Epidémiologie Génétique des Maladies Multifactorielles, Institut National de la Recherche et de la Santé Médicale</s1><s2>Evry</s2><s3>FRA</s3><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation></author><author><name sortKey="Mowry, Bryan J" sort="Mowry, Bryan J" uniqKey="Mowry B" first="Bryan J." last="Mowry">Bryan J. Mowry</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Queensland Centre for Schizophrenia Mental Health Research, The Park, Centre for Mental Health</s1><s2>Wacol</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Wacol</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Psychiatry, University of Queensland</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Amin, Farooq" sort="Amin, Farooq" uniqKey="Amin F" first="Farooq" last="Amin">Farooq Amin</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Atlanta VA Medical Center and Department of Psychiatry and Behavioral Sciences, Emory University</s1><s2>Atlanta</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Baylor College of Medicine</s1><s2>Houston</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Silverman, Jeremy M" sort="Silverman, Jeremy M" uniqKey="Silverman J" first="Jeremy M." last="Silverman">Jeremy M. Silverman</name><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>Department of Psychiatry, Mount Sinai School of Medicine</s1><s2>New York</s2><s3>USA</s3><sZ>14 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Black, Donald W" sort="Black, Donald W" uniqKey="Black D" first="Donald W." last="Black">Donald W. Black</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine</s1><s2>Iowa City</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>22 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Iowa City</wicri:noRegion></affiliation></author><author><name sortKey="Byerley, William F" sort="Byerley, William F" uniqKey="Byerley W" first="William F." last="Byerley">William F. Byerley</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Psychiatry, University of California at Irvine</s1><s2>Irvine</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Irvine</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Department of Psychiatry, University of California-San Francisco</s1><s2>San Francisco</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Crowe, Raymond R" sort="Crowe, Raymond R" uniqKey="Crowe R" first="Raymond R." last="Crowe">Raymond R. Crowe</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine</s1><s2>Iowa City</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>22 aut.</sZ><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Iowa City</wicri:noRegion></affiliation></author><author><name sortKey="Freedman, Robert" sort="Freedman, Robert" uniqKey="Freedman R" first="Robert" last="Freedman">Robert Freedman</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Psychiatry and Colorado Psychiatric Health, University of Colorado School of Medicine</s1><s2>Denver</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Denver</wicri:noRegion></affiliation></author><author><name sortKey="Cloninger, C Robert" sort="Cloninger, C Robert" uniqKey="Cloninger C" first="C. Robert" last="Cloninger">C. Robert Cloninger</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Psychiatry and Genetics, Washington University</s1><s2>St. Louis</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>St. Louis</wicri:noRegion></affiliation></author><author><name sortKey="Levinson, Douglas F" sort="Levinson, Douglas F" uniqKey="Levinson D" first="Douglas F." last="Levinson">Douglas F. Levinson</name><affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Department of Psychiatry, University of Pennsylvania</s1><s2>Philadelphia</s2><s3>USA</s3><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Philadelphie</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Gejman, Pablo V" sort="Gejman, Pablo V" uniqKey="Gejman P" first="Pablo V." last="Gejman">Pablo V. Gejman</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>18 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Evanston, IL</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">American journal of human genetics</title><title level="j" type="abbreviated">Am. j. hum. genet.</title><idno type="ISSN">0002-9297</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">American journal of human genetics</title><title level="j" type="abbreviated">Am. j. hum. genet.</title><idno type="ISSN">0002-9297</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>African American</term><term>CDKN1A Gene</term><term>Europe</term><term>European</term><term>Family study</term><term>Genetic determinism</term><term>Genetic linkage</term><term>Genetic mapping</term><term>Genetics</term><term>Genome</term><term>Human</term><term>Pathogenesis</term><term>Sample</term><term>Schizophrenia</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Schizophrénie</term><term>Génome</term><term>Pathogénie</term><term>Déterminisme génétique</term><term>Liaison génétique</term><term>Carte génétique</term><term>Européen</term><term>Europe</term><term>Afro Américain</term><term>Etude familiale</term><term>Gène CDKN1A</term><term>Echantillon</term><term>Génétique</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report the clinical characteristics of a schizophrenia sample of 409 pedigrees-263 of European ancestry (EA) and 146 of African American ancestry (AA)-together with the results of a genome scan (with a simple tandem repeat polymorphism interval of 9 cM) and follow-up fine mapping. A family was required to have a proband with schizophrenia (SZ) and one or more siblings of the proband with SZ or schizoaffective disorder. Linkage analyses included 403 independent full-sibling affected sibling pairs (ASPs) (279 EA and 124 AA) and 100 all-possible half-sibling ASPs (15 EA and 85 AA). Nonparametric multipoint linkage analysis of all families detected two regions with suggestive evidence of linkage at 8p23.3-q12 and llpll.2-q22.3 (empirical Z likelihood-ratio score [Z<sub>lr</sub>] threshold ≥2.65) and, in exploratory analyses, two other regions at 4p16.1-p15.32 in AA families and at 5p14.3-q11.2 in EA families. The most significant linkage peak was in chromosome 8p; its signal was mainly driven by the EA families. Z<sub>lr</sub> scores >2.0 in 8p were observed from 30.7 cM to 61.7 cM (Center for Inherited Disease Research map locations). The maximum evidence in the full sample was a multipoint Z<sub>lr</sub> of 3.25 (equivalent Kong-Cox LOD of 2.30) near D8S1771 (at 52 cM); there appeared to be two peaks, both telomeric to neuregulin 1 (NRG1). There is a paracentric inversion common in EA individuals within this region, the effect of which on the linkage evidence remains unknown in this and in other previously analyzed samples. Fine mapping of 8p did not significantly alter the significance or length of the peak. We also performed fine mapping of 4p16.3-p15.2, 5p15.2-q13.3, 10p15.3-p14, 10q25.3-q26.3, and 11p13-q23.3. The highest increase in Z<sub>lr</sub> scores was observed for 5p14.1-q12.1, where the maximum Z<sub>lr</sub> increased from 2.77 initially to 3.80 after fine mapping in the EA families.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>États-Unis</li></country><region><li>Californie</li><li>Illinois</li><li>Pennsylvanie</li><li>Texas</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Chicago</li><li>Houston</li><li>Philadelphie</li><li>San Francisco</li><li>Évry (Essonne)</li></settlement></list><tree><country name="États-Unis"><noRegion><name sortKey="Suarez, Brian K" sort="Suarez, Brian K" uniqKey="Suarez B" first="Brian K." last="Suarez">Brian K. Suarez</name></noRegion><name sortKey="Amin, Farooq" sort="Amin, Farooq" uniqKey="Amin F" first="Farooq" last="Amin">Farooq Amin</name><name sortKey="Amin, Farooq" sort="Amin, Farooq" uniqKey="Amin F" first="Farooq" last="Amin">Farooq Amin</name><name sortKey="Black, Donald W" sort="Black, Donald W" uniqKey="Black D" first="Donald W." last="Black">Donald W. Black</name><name sortKey="Buccola, Nancy G" sort="Buccola, Nancy G" uniqKey="Buccola N" first="Nancy G." last="Buccola">Nancy G. Buccola</name><name sortKey="Byerley, William F" sort="Byerley, William F" uniqKey="Byerley W" first="William F." last="Byerley">William F. Byerley</name><name sortKey="Byerley, William F" sort="Byerley, William F" uniqKey="Byerley W" first="William F." last="Byerley">William F. Byerley</name><name sortKey="Cloninger, C Robert" sort="Cloninger, C Robert" uniqKey="Cloninger C" first="C. Robert" last="Cloninger">C. Robert Cloninger</name><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J." last="Cox">Nancy J. Cox</name><name sortKey="Crowe, Raymond R" sort="Crowe, Raymond R" uniqKey="Crowe R" first="Raymond R." last="Crowe">Raymond R. Crowe</name><name sortKey="Cuiping Hou" sort="Cuiping Hou" uniqKey="Cuiping Hou" last="Cuiping Hou">CUIPING HOU</name><name sortKey="Duan, Jubao" sort="Duan, Jubao" uniqKey="Duan J" first="Jubao" last="Duan">Jubao Duan</name><name sortKey="Freedman, Robert" sort="Freedman, Robert" uniqKey="Freedman R" first="Robert" last="Freedman">Robert Freedman</name><name sortKey="Gejman, Pablo V" sort="Gejman, Pablo V" uniqKey="Gejman P" first="Pablo V." last="Gejman">Pablo V. Gejman</name><name sortKey="Green, Susan" sort="Green, Susan" uniqKey="Green S" first="Susan" last="Green">Susan Green</name><name sortKey="Hale, Nancy" sort="Hale, Nancy" uniqKey="Hale N" first="Nancy" last="Hale">Nancy Hale</name><name sortKey="Hinrichs, Anthony L" sort="Hinrichs, Anthony L" uniqKey="Hinrichs A" first="Anthony L." last="Hinrichs">Anthony L. Hinrichs</name><name sortKey="Jin, Carol H" sort="Jin, Carol H" uniqKey="Jin C" first="Carol H." last="Jin">Carol H. Jin</name><name sortKey="Levinson, Douglas F" sort="Levinson, Douglas F" uniqKey="Levinson D" first="Douglas F." last="Levinson">Douglas F. Levinson</name><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name><name sortKey="Olincy, Ann" sort="Olincy, Ann" uniqKey="Olincy A" first="Ann" last="Olincy">Ann Olincy</name><name sortKey="Rice, John P" sort="Rice, John P" uniqKey="Rice J" first="John P." last="Rice">John P. Rice</name><name sortKey="Sanders, Alan R" sort="Sanders, Alan R" uniqKey="Sanders A" first="Alan R." last="Sanders">Alan R. Sanders</name><name sortKey="Schaffer, Arthur W" sort="Schaffer, Arthur W" uniqKey="Schaffer A" first="Arthur W." last="Schaffer">Arthur W. Schaffer</name><name sortKey="Silverman, Jeremy M" sort="Silverman, Jeremy M" uniqKey="Silverman J" first="Jeremy M." last="Silverman">Jeremy M. Silverman</name><name sortKey="Smith, Christopher J" sort="Smith, Christopher J" uniqKey="Smith C" first="Christopher J." last="Smith">Christopher J. Smith</name><name sortKey="Weilbaecher, Ann N" sort="Weilbaecher, Ann N" uniqKey="Weilbaecher A" first="Ann N." last="Weilbaecher">Ann N. Weilbaecher</name></country><country name="Australie"><noRegion><name sortKey="Nertney, Deborah A" sort="Nertney, Deborah A" uniqKey="Nertney D" first="Deborah A." last="Nertney">Deborah A. Nertney</name></noRegion><name sortKey="Hannah, Dominique E" sort="Hannah, Dominique E" uniqKey="Hannah D" first="Dominique E." last="Hannah">Dominique E. Hannah</name><name sortKey="Hannah, Dominique E" sort="Hannah, Dominique E" uniqKey="Hannah D" first="Dominique E." last="Hannah">Dominique E. Hannah</name><name sortKey="Mowry, Bryan J" sort="Mowry, Bryan J" uniqKey="Mowry B" first="Bryan J." last="Mowry">Bryan J. Mowry</name><name sortKey="Mowry, Bryan J" sort="Mowry, Bryan J" uniqKey="Mowry B" first="Bryan J." last="Mowry">Bryan J. Mowry</name><name sortKey="Nertney, Deborah A" sort="Nertney, Deborah A" uniqKey="Nertney D" first="Deborah A." last="Nertney">Deborah A. Nertney</name></country><country name="France"><region name="Île-de-France"><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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